Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice

March 30, 2010 (Albany, N.Y., USA )- -In this publication with researchers from Harvard, Dana-Farber Cancer Center, and several other institutions, Intidyn founder Frank L. Rice contributes to an important study identifying a likely cause of itch – a poorly understood condition that affects us all. In it, the researchers show that the loss of specific inhibitory neurons – rather than overactivation of itch receptors -- enables persistent itching to occur. The discovery of this mechanism opens important new avenues for the control of chronic pathological itching conditions, in which itch is so intense and unceasing that people and animals with this condition often injure themselves.

Article Link: https://www.cell.com/neuron/abstract/S0896-6273(10)00142-X?script=true   

About Integrated Tissue Dynamics (INTIDYN)

Integrated Tissue Dynamics, LLC, also known as INTIDYN, provides flexible and scalable research capabilities on behalf of pharmaceutical companies to detect chemical and structural changes in the skin that may cause the chronic numbness, pain and itch associated with a wide variety of afflictions such as diabetes, shingles, complex regional pain syndrome, carpal tunnel syndrome, sciatica, fibromyalgia, psoriasis, chemotherapy and even the unintended side effects caused by many drugs. Such afflictions and the associated neurological problems respond poorly to existing treatments.

Contact:

Dr. Frank L. Rice, PhD
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Integrated Tissue Dynamics (INTIDYN)