Dear Colleague,

Integrated Tissue Dynamics, also called INTIDYN, was established in 2008 to translate more than 35 years of experience in complex tissue analysis from the laboratory to the development of effective and safe therapeutics.

Founded by myself and Phillip J. Albrecht, Ph.D., INTIDYN specializes in assessing the impact of disease, toxins, and/or pharmacotherapies on the developmental dynamics, peripheral neural innervation,  chemistry and morphology of complex tissue.  Our focus on the multiple, integrated systems within complex tissues provides our clients with rich and comprehensive data about the cumulative physical transformations, biomolecular signaling, and gene regulations taking place in an intact living system.

All of our work is based on our proprietary INTIDYN ChemoMorphometric Analysis (ITD-CMA) platform.  ITD-CMA provides a 3-part methodology that integrates (1) multi-molecular immunochemistry, (2) tissue morphology, and (3) genomics to bridge the gap between basic research and clinical treatment.  Using validated qualitative and quantitative methodologies, ITD-CMA has been successfully applied in numerous collaborations across a variety of human specimens and animal models.

While applicable to all complex tissues, to date, INTIDYN has made especially significant progress utilizing ITD-CMA in skin, focusing on the interactions of the nervous, cardiovascular and endocrine systems in this exquisitely complex organ.  Skin, in particular, is an excellent end-point assay organ because it is exposed to a wide variety of insults, is large and contains regional variability, and is easily accessed compared to internal organs.  Skin is also one of the most complex multi-system organs in mammals, offering a cost-effective and practical site for the analysis of the integration of its many different systems (e.g., nervous, cardiovascular, endocrine, immune) and functions (e.g., protection, thermoregulation, regeneration, sensation, inflammation).

Because physical, nutritional, or xenobiotic pathologic insults often have a cascading impact across multiple disparate but integrated systems, the skin and its innervation and blood supply are the sites of hundreds of chronic, debilitating dermatopathies, neuropathies, and vasculopathies that notoriously respond poorly to existing therapeutics.  Furthermore, the complex interaction of the multiple systems within the skin make this organ highly vulnerable to environmental toxins and pharmaceutical drug side-effects.  Most importantly, its complexity also enables us to observe changes within these systems prior to overt disease or dysfunction.

We invite you to contact us to learn more about the many ways INTIDYN can work with you to investigate complex tissues and to develop the actionable data needed to advance your project.

Very Sincerely Yours,

Frank L. Rice, PhD
CEO and Chief Scientist